Arsenal could still finish the season with silverware, but success in the FA Cup is no longer enough for a sizeable number of Gunners fans.
They are out of the
Champions League and a top-four finish is far from guaranteed as they currently sit fifth, two points behind Liverpool.
Those fans who feel Wenger has taken the side as far as they can go made their feelings known before the game with a protest - their second in a week after around 200 supporters expressed their frustration before the Champions League last-16 second leg tie with Bayern Munich on Tuesday.
But there was support for Wenger inside the ground as some fans held 'In Wenger we trust' banners, while on the pitch his players stepped up after a slow start.
Mesut Ozil was particularly influential after his 27th minute introduction and Sanchez, whose long-term future at the Emirates is reportedly in doubt, impressed with a fine goal and an assist.