There was also a red card for FC Copenhagen substitute Jan Gregus during the closing moments of his side's 2-1 win at Ludogorets.
A late header from Takayuki Seto earned Astra Giurgiu a 2-2 draw against Genk.
Fiorentina left Borussia Monchengladbach with a 1-0 victory, while Shakhtar Donetsk won at Celta Vigo by the same scoreline.
Olympiacos had Brazilian defender Bruno Viana sent off during the closing stages of their goalless draw against Osmanlispor.
Lacazette, a summer target for Arsenal, has 25 goals across all competitions for Lyon
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Legia Warsaw played out a goalless draw at home to Ajax while Anderlecht beat Zenit St Petersburg 2-0 at the Constant Vanden Stock Stadium.
In Thursday's other earlier kick-offs, Alexandre Lacazette scored twice as Lyon won 4-1 at AZ Alkmaar.
Sparta Prague saw Ivory Coast forward Tiemoko Konate sent off for collecting two yellow cards in the first half as they went down 4-0 away to Rostov.